EDITORES Y COMITÉ EDITORIAL

EDITORES

MARK H. BEERS, M.D.
Senior Director of Geriatrics Merck & Co., Inc., and Clinical Associate Professor of Medicine, Allegheny University of the Health Sciences

EDITORES JEFES ASOCIADOS

ROBERT M. BOGIN, M.D.
Merck & Co., Inc., and Clinical Associate Professor of Medicine, Allegheny University of the Health Sciences

COMITÉ EDITORIAL

PHILIP K. BONDY, M.D.
Professor of Medicine (Emeritus), Yale University

PRESTON V. DILTS, JR., M.D.
Professor of Obstetrics and Gynecology (Emeritus), University of Missouri at Kansas City

DOUGLAS A. DROSSMAN, M.D.
Professor of Medicine and Psychiatry, University of North Carolina at Chapel Hill

L. JACK FALING, M.D.
Clinical Professor of Medicine, Boston University; Associate Chief of Medicine, Boston VA Medical Center

EUGENE P. FRENKEL, M.D.
Professor of Internal Medicine and Radiology, Patsy R. and Raymond D. Nasher Distinguished Chair in Cancer Research, and A. Kenneth Pye Professorship in Cancer Research, Division of Hematology-Oncology, Department of Medicine, The University of Texas Southwestern Medical Center at Dallas

GLEN O. GABBARD, M.D.
Callaway Distinguished Professor, The Menninger Clinic

ROBERT BERKOW, M.D.
Executive Director of Medical Literature Merck & Co., Inc., and Clinical Professor of Medicine and Psychiatry, Allegheny University of the Health Sciences

ANDREW J. FLETCHER, M.B., B.Chir.
Merck & Co., Inc., and Adjunct Professor of Pharmaceutical Health Care, Temple University

ROBERT A. HOEKELMAN, M.D.
Professor and Chairman of Pediatrics (Emeritus), University of Rochester

GERALD L. MANDELL, M.D.
Professor of Medicine, Owen R. Cheatham Professor of the Sciences, University of Virginia; Chief, Division of Infectious Diseases, University of Virginia Health Sciences Center

FRED PLUM, M.D.
University Professor and Chairman of Neurology (Emeritus), Cornell University; Attending Neurologist, The New York Hospital-Cornell Medical Center

G. VICTOR ROSSI, Ph.D.
Leonard and Madlyn Abramson Professor of Pharmacology, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia

PAUL H. TANSER, M.D., F.R.C.P.(C)
Professor of Medicine, McMaster University; Senior Cardiologist, St. Joseph's Hospital, Hamilton, Ontario, Canadá

CONSULTORES

JAMES C. BALLENGER, M.D.

Chairman and Professor, Department of Psychiatry and Behavioral Sciences, and Director, Institute of Psychiatry, Medical University of South Carolina

Trastornos psiquiátricos

WILLIAM M. BENNETT, M.D.

Professor of Medicine and Pharmacology, Oregon Health Sciences University

Trastornos genitourinarios

JOSEPH W. BERKOW, M.D.

Assistant Professor of Ophthalmology, Johns Hopkins University

Oftalmología

INA LEE STILE CALLIGARO, Pharm.D.

Associate Professor and Clinical Pharmacist, Pediatrics, and Chairperson, Department of Pharmacy Practice, Temple University

Preparados farmacéuticos y posologías pediátricas

RALPH E. CUTLER, M.D.

Professor of Medicine and Pharmacology, Loma Linda University; Chief of Nephrology, Pettis Memorial VA Medical Center

Trastornos genitourinarios

MARK V. DAHL, M.D.

Professor and Chairman, Department of Dermatology, University of Minnesota

Trastornos dermatológicos

GEORGE E. DOWNS, Pharm.D

Professor of Clinical Pharmacy and Dean, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia

Preparados farmacéuticos y posologías

EDWARD J. FINE, M.D.

Associate Professor of Neurology, State University of New York at Buffalo

Neurología

SUSAN HENDRIX, D.O.

Assistant Professor of Obstetrics and Gynecology and Director, Women's Health Initiative, Wayne State University/Hutzel Hospital

Ginecología y obstetricia

CHARLES S. HOUSTON, M.D.

Professor of Medicine (Emeritus), University of Vermont

Trastornos causados por agentes físicos

PETER LAIBSON, M.D.

Director, Corneal Service, Wills Eye Hospital

Oftalmología

JOSÉ J. LLINAS, M.D.

Clinical Professor of Psychiatry, College of Medicine, University of Florida; Medical Director, Meridian Behavioral Health Care, Gainesville

Trastornos psiquiátricos

MORTIMER LORBER, D.M.D., M.D.

Associate Professor of Physiology and Biophysics, Georgetown University

Patología dental y oral

JOANNE LYNN, M.D.

Professor of Health Care Sciences and Medicine, The George Washington University: Director, The Center to Improve Care of the Dying

Temas especiales

BRUCE C. PATON, M.D.

Clinical Professor of Surgery, University of Colorado Health Sciences Center

Trastornos causados por agentes físicos

HAL B. RICHERSON, M.D.

Professor of Internal Medicine (Emeritus), University of Iowa

Inmunología; enfermedades alérgicas

ROBERT J. RUBEN, M.D.

Chairman, Otolaryngology, Albert Einstein College of Medicine, Montefiore Medical Center

Otorrinolaringología

H. RALPH SCHUMACHER, JR., M.D.

Professor of Medicine, University of Pennsylvania; Director, Arthritis-Immunology Center, VA Medical Center, Filadelfia

Enfermedades musculoesqueléticas y del tejido conjuntivo

RUTH W. SCHWARTZ, M.D.

Professor of Obstetrics and Gynecology, University of Rochester

Ginecología y obstetricia

WARREN R. SELMAN, M.D.

Professor of Neurological Surgery and Vice Chairman, Department of Neurological Surgery, Case Western Reserve University and University Hospitals of Cleveland

Neurología

ROBERT A. SINKIN, M.D.

Associate Professor of Pediatrics, University of Rochester; Medical Director of NICU, Children's Hospital at Strong

Pediatría

Revisores de capítulos seleccionados:

Sarah Atkinson, M.D.

Robert N. Butler, M.D.

Andrea Calabrese, Pharm.D.

Steven Frucht, M.D.

Terry Fulmer, Ph.D., R.N.

Mateel Graham, M.D.

Cynthia Harden, M.D.

Kurt Hirschhorn, M.D.

Jonathan Jay, M.D.

Philip Landrigan, M.D., M.Sc.

Frank W. LoGerfo, M.D.

John S. Macdonald, M.D.

James V. Mackell, M.D.

Donald E. Mock, Ph.D.

Pekka Mooar, M.D.

Richard Moon, M.D.

David R. Nalin, M.D.

John C. Nemiah, M.D.

Robert Ratcheson, M.D.

Henry Rosenberg, M.D.

Findley E. Russell, M.D., Ph.D.

George L. Spaeth, M.D.

Margaret A. Winker, M.D.

Virgil Wooten, M.D.

Vincent Zarro, M.D.

EDICIÓN ESPAÑOLA

ASESOR CIENTÍFICO PROF. DR. EVARIST FELIU FRASNEDO

Profesor Titular de Medicina.

Autónoma de Barcelona. Jefe del Servicio de Hematología y Hemoterapia.

Germans Trias i Pujol. Badalona. Barcelona.

SUPERVISIÓN TÉCNICA DR. JUAN MANUEL SANCHO CÍA

Universidad Especialista en Hematología y Hemoterapia.

Médico Adjunto. Hospital Universitari

Hospital Universitari

Germans Trias i Pujol. Badalona. Barcelona

Traducción al castellano realizada por el departamento médico de DIORKI, Servicios Integrales de Edición:

COORDINADOR

DR. RAFAEL VILLANUEVA ALFONSO

Universidad de Valencia. Especialista en Medicina Interna

DRA. ISABEL ÁLVAREZ BALERIOLA

Jefa del Servicio de Anatomía Patológica. Hospital Ramón y Cajal. Madrid

DR. ENRIQUE ARTOZQUI MORRAS

Especialista en Endocrinología, Metabolismo y Nutrición. Hospital Nuestra Señora de Aránzazu. San Sebastián

DR. JOSÉ BAENA DÍAZ

Especialista en Traumatología y Ortopedia. Hospital General de El Escorial. Servicio de Traumatología

DRA. MARÍA LUISA CAÑETE LÓPEZ

Universidad Complutense de Madrid. Especialista en Ginecología y Obstetricia

DR. JOSÉ IGNACIO CHACÓN LÓPEZ-MUÑIZ

Especialista en Oncología Radioterápica. Servicio de Oncología Médica. Hospital Virgen de la Salud. Toledo

DR. JOSÉ ANTONIO DOMÍNGUEZ DELGADO

Especialista en Medicina Interna. Servicio de Medicina Interna. Hospital San Francisco de Asís. Madrid

DRA. MARÍA JESÚS FERNÁNDEZ ACEÑERO

Especialista en Anatomía Patológica. Servicio de Anatomía Patológica. Hospital General de Móstoles. Madrid

DR. DANIEL FONT VERA

Universidad Complutense de Madrid. Médico Psicoterapeuta

DR. ALFREDO GARCÍA PASSIGLI

Universidad Complutense de Madrid. Especialista en Cardiología

DR. LAWRENCE GARRO GUERRERO

Universidad Autónoma de Madrid. Especialista en Cirugía Plástica y Reparadora

DR. RICARDO GAYA MORENO

Universidad de Granada. Especialista en Oftalmología. Servicio de Oftalmología. Hospital Valle de los Pedroches. Pozoblanco. Córdoba

DRA. MARÍA JOSÉ HERNÁNDEZ WEIGAND

Universidad Autónoma de Madrid. Licenciada en Medicina y Cirugía

DR. JUAN MANUEL IGEA AZNAR

Universidad Complutense de Madrid.Especialista en Alergología e Inmunología

PROF. DR. JUAN CARLOS LEZA CERRO

Profesor Titular del Departamento de Farmacología. Facultad de Medicina. Universidad Complutense de Madrid

PROF. DR. JUAN IGNACIO LIZASOAIN HERNÁNDEZ

Profesor Titular del Departamento de Farmacología. Facultad de Medicina. Universidad Complutense de Madrid

DRA. MARGARET LLANOS TAYLOR

Universidad Nacional Autónoma de Honduras. Especialista en Otorrinolaringología

PROF. DR. CARMELO LUIS LÓPEZ-ARIAS CALLEJO

Catedrático Emérito de Bioquímica y Biología Molecular de la Facultad de Medicina. Universidad de Salamanca

DR. RAFAEL LUNA MÉNDEZ

M.I.R. en Medicina Familiar y Comunitaria. Clínica Puerta de Hierro. Madrid

DR. SAÚL POLÍN BENÍTEZ

Universidad Privada Cayetano Heredia. Lima. Especialista en Urología

DR. JUAN JOSÉ SÁNCHEZ RUANO

Universidad Autónoma de Madrid. Especialista en Gastroenterología y Hepatología

DRA. VICTORIA TORRES-PARDO VEGA

Universidad de Valladolid. Especialista en Neurología.

AURELIO VELASCO CERRUDO

Especialista en Microbiología y Parasitología. Hospital Severo Ochoa. Madrid